Everything You Need to Know About Nicotinamide

Riboside Chloride

  1. Why We Need Nicotinamide Riboside Chloride

The cosmetic industry is a billion-dollar industry, primarily because human beings are obsessed with the way they look. This is also the key factor why the research around anti-ageing ingredients and products has made such incredible advances in such a short time. Global conglomerates understand that there is money to made from individuals’ desire to stay forever young and thus, have teams in place, devoting days and weeks to find ingredients and products that can enhance skin vitality. Nicotinamide Riboside or Niagen was discovered as a result of this unabated search for anti-ageing products. While most anti-ageing products minimize signs of ageing from the skin, Niagen minimizes signs of ageing within the body. Nicotinamide Riboside or Niagen is the crystal form of Nicotinamide Riboside Chloride and once within the body, it converts into NAD+, which is responsible for healthy ageing as well as various other crucial functions.

  1. What is Nicotinamide Riboside Chloride?

Forget about the big and complicated name. Nicotinamide Riboside Chloride CAS 23111-00-4 is actually an alternative form of Vitamin B3, often referred to as niacin. Nicotinamide Riboside Chloride may also be called niagen or shortened as NR. Once ingested in the body, it will be converted into Nicotinamide adenine dinucleotide or NAD+. NAD+ is one of the most important enzymes in human physiology.

It is responsible for fueling a number of key biological processes including the conversion of food into energy and fortifying the defense systems found within each cell. The enzyme may also be crucial in repairing damaged DNA and can have an additional positive effect in promoting healthy aging. The body can produce its own NAD+ enzyme easily without supplementation. The sad part is that, as you continue to age, the amount of NAD+ produced by the body declines.

In essence, older people will have lower levels of this important enzyme compared to younger ones. This is where supplementation becomes very important. Using Nicotinamide Riboside Chloride supplements to enhance NAD+ levels, especially among older people, may offer a number of incredible benefits.

First of all, declining levels of NAD+ have been likened to age-related chronic illness including diabetes, Alzheimer’s, heart failure, and vision loss. There is also some evidence showing that rising NAD+ may reverse signs of aging. Ultimately, the use of a Nicotinamide Riboside chloride supplement does not only help you look younger and more confident. It also helps to lower the possible risk of chronic illnesses as you age.

  1. Nicotinamide Riboside Chloride Dosage

The five studies conducted so far have established that Nicotinamide Riboside is safe for human usage. However, these studies have established the safe Nicotinamide Riboside Chloride dosage limit for human beings between 1,000 to 2,000 mg per day. However, it must be kept in mind that all of the studies that analyzed the safety of Nicotinamide Riboside had a very small sample size and thus, more research is needed in this area.

The primary purpose of Nicotinamide Riboside Chloride is to essentially provide Nicotinamide Riboside Chloride or Niagen to the body. Niagen or NR is usually available in two forms: tablets and capsules. Many Nicotinamide Riboside supplement manufacturers combine NR with other chemicals, such as Pterostilbene. In any case, to be safe, most supplement manufacturers recommend keeping the daily intake of NR between 250 to 300 mg per day.

  1. Is Nicotinamide Riboside Chloride Safe?

The several studies conducted so far have found Nicotinamide Riboside consumption in the range 1000 to 2000 mg per day safe for human usage. However, since more concrete studies are needed in this area, Nicotinamide Riboside manufacturers recommend keeping one’s daily intake of NR under 250-300 mg per day.

Though Nicotinamide Riboside or Nicotinamide Riboside Chloride consumption is safe, it can lead to side-effects such as nausea, headaches, indigestion, fatigue and diarrhoea. If you experience any of these symptoms while taking an NR supplement, immediately consult your doctor. Moreover, since there isn’t enough evidence regarding the effect of Nicotinamide Riboside on pregnant and breastfeeding women, this group should steer away from the use of Nicotinamide Riboside supplements.

  1. Nicotinamide Riboside Chloride Supplement

If you are looking for a vegetarian Nicotinamide Riboside Chloride supplement, we recommend Tru Niagen Nicotinamide Riboside supplement. This supplement uses NIAGEN, the company’s patented NR product. The manufacturing company deals only with Nicotinamide Riboside supplements and therefore, one can rest assured that the supplements created by the company are of very high quality. The Tru Niagen Nicotinamide Riboside supplement comes in easy-to-consume capsules, which are quite easy-to-swallow. Users are required to take only one capsule per day.

However, if you are looking for a gluten, egg, BPA, nuts, preservatives and dairy-free product, we recommend putting your money in the Thorne ResveraCel Nicotinamide Riboside supplement. This supplement combines NR with flavonoids. Together, these two enhance sirtuin activity. More importantly, Thorne ResveraCel claims that it does four rounds of testing on each of its supplement and thus, the company’s supplements are perfectly safe. Further, these supplements are produced in a cGMP certified facility in the United States and a TGA certified facility in Australia.

  1. Where to Buy Nicotinamide Riboside Chloride Powder in Bulk?

The demand for Nicotinamide Riboside supplements has increased considerably over the last few years, primarily because Nicotinamide Riboside has many advantages. If you are looking to foray into the Nicotinamide Riboside supplements market, the first thing you must do is find yourself a trustworthy and reliable raw materials supplier. Where to buy Nicotinamide Riboside Chloride powder in bulk? The answer is Cofttek.

Cofttek is a raw materials supplier that came into existence in 2008 and in only about a decade, the company has established its presence in several countries. Other than producing reliable products, the company is also focussed on making advances in the field of biotechnology, chemical technology and chemical testing. The company is also committed to quality research, which gives it an edge over other suppliers in the market. The Nicotinamide Riboside Chloride powder  provided by the company comes in batches of 25 kgs and can be trusted for quality. Moreover, the company has excellent sales and customer support team which will take care of all your needs and enquiries in real-time. This, if you want to buy Nicotinamide Riboside Chloride powder in bulk, trust only Cofttek..



  1. Conze, D., Brenner, C. & Kruger, C.L. Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults. Sci Rep9, 9772 (2019)


  1. Carlijn M E Remie, Kay H M Roumans, Michiel P B Moonen, Niels J Connell, Bas Havekes, Julian Mevenkamp, Lucas Lindeboom, Vera H W de Wit, Tineke van de Weijer, Suzanne A B M Aarts, Esther Lutgens, Bauke V Schomakers, Hyung L Elfrink, Rubén Zapata-Pérez, Riekelt H Houtkooper, Johan Auwerx, Joris Hoeks, Vera B Schrauwen-Hinderling, Esther Phielix, Patrick Schrauwen, Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans, The American Journal of Clinical Nutrition, Volume 112, Issue 2, August 2020, Pages 413–426


  1. Elhassan,Y. S., Kluckova, K., Fletcher, R. S., Schmidt, M. S., Garten, A., Doig, C. L., Cartwright, D. M., Oakey, L., Burley, C. V., Jenkinson, N., Wilson, M., Lucas, S., Akerman, I., Seabright, A., Lai, Y. C., Tennant, D. A., Nightingale, P., Wallis, G. A., Manolopoulos, K. N., Brenner, C., … Lavery, G. G. (2019). Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures. Cell reports, 28(7), 1717–1728.e6.